The Sildenafil story(Viagra)

It would not become a drug for heart diseases, researchers at Pfizer sighed. 

For years they worked on sildenafil, an inhibitor of the PDE5 enzyme, which they hoped would be effective in relaxing coronary arteries and relieving chest pain. 
Their hope was dashed by 1992. Only one out of ten candidates entering clinical trials successfully passes through the gauntlet and reaches consumers, but statistics is little consolation for those who see their projects falling on the heap of nine. 
Gloomily, the researchers terminated the trial and asked participants to return the unused drug. 


Many men refused, clutching to the drug as if it was gold.  Idiosyncrasies being present in all clinical tests, researchers gave the objection little thought until they heard rumors about the drug’s side effects on sex life and, more important, read a paper on the role of PDE5 in the chemical pathway of erection. 

Gloom evaporated in the excitement that sildenafil may be a blockbuster after all.  This time, their expectation was confirmed by new clinical tests on impotent men.  They stumbled on an effective drug for erectile dysfunction Pfizer would market as Viagra.

Friends, we always think what will we gain from the history?? in the least place why do we even study it or think about it??
I have the answer for you....History provides us with the lessons and guides us to  not to repeat the mistakes.....so, i think you all got it!!


2 lessons to be learnt from this story..

"Never lose Hope....hard work doesnt go fruitless"
 "Chance favors a prepared mind.  Success favors an open and persevering mind." 

Posted in: sildenafil,VIAGRA